Psoriasis is a skin condition which is characterized by an abnormal growth rate of skin cells. This produces silvery, yellow-white scales on the surface of the skin. Most of the skin changes, except for inflammation, can be explained by the rapid turnover of the epidermal skin cells. Normal skin produces about 1,250 cells a day for each square centimeter, and these come from 27,000 basal cells. Psoriatic skin produces 35,000 new cells each day for each square centimeter, and these come from 27,000 basal cells. Psoriatic skin produces 35,000 new cells each day for each square centimeter, and these come from over 52,000 basal cells! The normal duration of the cell cycle of skin is 311 hours, but it's reduced to 36 hours for psoriatic skin! Some people develop an associated arthritis that's similar to rheumatoid arthritis, which sometimes resolves itself but other times can be very difficult to treat.
No one knows for sure what causes this condition, but it's been theorized that it may be from a faulty utilization of fats or some sort of suppression of the immune system. People with HIV or AIDS often have severe psoriasis. Psoriasis is not contagious.
In researching possible mechanisms of action and trying to determine why Collastin has been found to be so effective in treating this condition, one physiological pathway keeps coming up. Once again, the leukotrienes (in particular leukotriene B4, the one with the potent chemotactic effect) have been found to play an important role in producing the inflammation and the deregulation to the growth rate of skin cells. Leukotrienes are produced from arachadonic acid in the presence of the enzyme lipoxygenase. In communicating with other health care providers as to Collastin's mechanism of action, they concur that interference with this pathway seems to be a plausible explanation. However, more research needs to be done before we will know for sure.
Margaret's Experience with Psoriatic Arthritis
Margaret is 48 years old. At 19 years old she was diagnosed with psoriatic arthritis. She was told that nothing could be done and was instructed to take pain pills to keep comfortable. She was also told that one day she would, more than likely, be confined to a wheelchair.
By the time she was 30 years old, both of her knees were completely frozen and the pain throughout her body was excruciating. The pain pills were no longer working. Her only options - at this point - were to be bedridden, in a wheelchair, or have joint replacement surgery performed. Within three years she not only had both knees replaced, but both hip joints, as well.
Three months ago, she started taking a mixture of fatty acid esters found in Collastin. After only three days, she started to experience a feeling of well-being. Within two weeks, she started to forget to take her pain pills. And two months later -- for the first time in 20 years -- she was completely pain free!
Psoriasis is a skin condition which is characterized by an abnormal growth rate of skin cells. This produces silvery, yellow-white scales on the surface of the skin. Most of the skin changes, except for inflammation, can be explained by the rapid turnover of the epidermal skin cells. Normal skin produces about 1,250 cells a day for each square centimeter, and these come from 27,000 basal cells. Psoriatic skin produces 35,000 new cells each day for each square centimeter, and these come from 27,000 basal cells. Psoriatic skin produces 35,000 new cells each day for each square centimeter, and these come from over 52,000 basal cells! The normal duration of the cell cycle of skin is 311 hours, but it's reduced to 36 hours for psoriatic skin! Some people develop an associated arthritis that's similar to rheumatoid arthritis, which sometimes resolves itself but other times can be very difficult to treat.
